Table 4.
Association Analysis of OS and Clinical Characteristics of LUAD Patients (Cox Regression)
| Characteristics | Total (N) | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P value | Hazard Ratio (95% CI) | P value | ||
| T stage (T2&T3&T4 vs T1) | 523 | 1.728 (1.229–2.431) | 0.002 | 1.247 (0.728–2.136) | 0.422 |
| N stage (N1&N2&N3 vs N0) | 510 | 2.601 (1.944–3.480) | <0.001 | 1.457 (0.904–2.347) | 0.122 |
| M stage (M1 vs M0) | 377 | 2.136 (1.248–3.653) | 0.006 | 1.177 (0.451–3.074) | 0.739 |
| Pathologic stage (Stage III &Stage IV vs Stage I & Stage II) | 518 | 2.664 (1.960–3.621) | <0.001 | 1.925 (1.063–3.485) | 0.031 |
| Primary therapy outcome (CR vs PD&SD&PR) | 439 | 0.372 (0.265–0.521) | <0.001 | 0.298 (0.181–0.490) | <0.001 |
| Gender (Male vs Female) | 526 | 1.070 (0.803–1.426) | 0.642 | ||
| Race (White vs Asian & Black or African American) | 468 | 1.475 (0.902–2.411) | 0.121 | ||
| Age (>65 vs ≤65) | 516 | 1.223 (0.916–1.635) | 0.172 | ||
| Residual tumor (R1&R2 vs R0) | 363 | 3.879 (2.169–6.936) | <0.001 | 4.736 (1.959–11.451) | <0.001 |
| Anatomic neoplasm subdivision (Right vs Left) | 512 | 1.037 (0.770–1.397) | 0.810 | ||
| Anatomic neoplasm subdivision 2 (Peripheral Lung vs Central Lung) | 182 | 0.913 (0.570–1.463) | 0.706 | ||
| Number_pack_years_smoked (≥40 vs <40) | 363 | 1.073 (0.753–1.528) | 0.697 | ||
| Smoker (Yes vs No) | 512 | 0.894 (0.592–1.348) | 0.591 | ||
| ADAMTS9-AS2 (High vs Low) | 526 | 0.683 (0.511–0.914) | 0.010 | 0.626 (0.397–0.986) | 0.043 |