Figure 6.

The vervet model of AD-like neuropathology and related behavioral and physiological characteristics.(a) Potential relationships between metabolic state and AD biomarkers in the plasma and CSF (adapted from Kavanagh et al., 2019). (b) The measurement of walking speed. Marks were made with indelible markers at visible points on various structures throughout the home pens. Each landmark was given an identification (e.g. A, B…etc.), and distances between landmarks were measured. Every time a subject passed a landmark they were timed with a stopwatch until they passed another landmark, and time and landmarks were recorded. Walking speed was calculated as distance/time. (c) Older adult vervets had a lower Firmicutes:Bacteroidetes ratio than did younger adults (p=0.03) (adapted from Vemuri et al., 2020). (d) Two examples from the Wake Forest Maze Task of executive function; examples of an easy (left) maze and difficult (right) maze. (e) Coronal sections illustrating the density of Aβ pathology; illustrated by heat map (adapted from Latimer et al., 2019).