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. 2021 Nov 27;19:392. doi: 10.1186/s12951-021-01069-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The overproduction of H₂S in human CRC. A, B H₂S production measured in human colorectal cancer specimens (*P < 0.05 vs. normal mucosa) and in colorectal cancer cell lines (*P < 0.05 vs. NCM460 cells; n.s.: no significant difference v.s. MCF-10A) by the H₂S microsensor. (T: tumor tissue; A: aside colorectal tumor tissue; N: normal colorectal tissue). C H₂S production in different stage of human colorectal cancer specimens measured by the H₂S microsensor. D Western Blot of CBS protein expression in human colorectal cancer specimens, paired with the adjacent tissue and corresponding normal mucosa tissues. Membranes are re-probed for GAPDH expression to show that similar amounts of protein were loaded in each lane. E Immunohistochemistry of CBS protein expression in human colorectal cancer specimens, paired with the adjacent tissue and corresponding normal mucosa tissues. F Western Blot of CBS protein expression in colon cancer cell lines (vs. NCM460). G H₂S production is measured in colon cancer cell lines treated by AOAA. H Cell viability of the HCT116 and CT26 treated with AOAA for 24 h. I Cell growth of the HCT116 and CT26 treated with AOAA within 6 days. (*P < 0.05), (n.s.: No significant difference, P value > 0.05)