Table 2.
Proteins selected from LASSO or random forest when comparing affected and unaffected individuals
| Protein | Description | Uniprot | Antibody | LASSO % selected |
Random forest Mean mda |
|---|---|---|---|---|---|
| NEFM* | Neurofilament medium polypeptide | P07197 | HPA022845 | 100 | 28.1 |
| NPTX2* | Neuronal pentraxin 2 | P47972 | HPA049799 | 71.6 | 8.4 |
| VGF* | Neurosecretory protein VGF | O15240 | HPA055177 | 40.2 | 9.2 |
| AQP4* | Aquaporin 4 | P55087 | HPA014784 | 26.5 | 11.3 |
| APOE4 | Apolipoprotein E isoform 4 | Q8TCZ8 | M067–3 | 55.6 | 0.8 |
| SEC63 | Translocation protein SEC63 homolog | Q9UGP8 | HPA053295 | 40.2 | 3.1 |
| APOA1 | Apolipoprotein A1 | P02647 | HPA046715 | 31.5 | 4.2 |
| PTPRN2 | Protein tyrosine phosphatase, receptor type N2 | Q92932 | HPA007255 | 8.8 | 8.2 |
| CTSS | Cathepsin S | P25774 | HPA002988 | 7.6 | 9.4 |
| SERPINA3 | Serpin family A member 3 | P01011 | HPA000893 | 0 | 12.8 |
| C4A/B | Complement C4A, complement C4B | P0C0L4, P0C0L5 | HPA046356 | 0 | 11.0 |
| AMPH | Amphiphysin | P49418 | HPA019829 | 0 | 9.5 |
| SPP1 | Secreted phosphoprotein 1 | P10451 | NBP2–37423 | 0 | 8.8 |
| CD14 | Monocyte differentiation antigen CD14 | P08571 | HPA002035 | 0 | 8.5 |
Asterisk next to the protein name show which proteins were selected by both LASSO and Random forest. Proteins with grey numbers in the LASSO or Random forest columns did not meet the selected cut-off for that model. LASSO indicates in how many models a protein was selected (% out of 1000 models). Random forest indicates the mean mda from 1000 models