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. 2021 Nov 26;22:856. doi: 10.1186/s12864-021-08175-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Signal peptide prediction for wt, p.Leu18del and p.Gly22Arg PMEL variants. Plotted are the probabilities reported by Signal P-5.0 for a signal peptide (solid red line), for the cleavage site (dashed green line) and for no signal peptide (dotted yellow line) in the indicated PMEL variants. Arrowheads indicated the predicted cleavage sites