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. 2021 Nov 27;20:121. doi: 10.1186/s12938-021-00959-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Combined analysis of AS events and expression profile in UC patients. A PCA plot of 4 UC versus 4 control expression profile using the top 2000 regulated genes as variables. B Scatterplot pairs of first three principal components for Percent Spliced In (PSI) values across 8 samples. The red triangles represent UC disease patients and the blue circle represent normal samples. C Venn diagram showed overlapped genes involved in expression regulation and AS regulation