Table 2.
Univariate analysis of the risk factors related to distant metastasis in de novo NPC patients
| DM positive N = 244(%) |
DM negative N = 4225(%) |
OR (95%CI) | P | |
|---|---|---|---|---|
| Gender | 0.000 | |||
| Male | 206 (84.43) | 3063 (72.50) | 1 | – |
| Female | 38 (15.57) | 1162 (27.50) | 0.486 (0.342–0.692) | – |
| Age | 0.062 | |||
| ≤ 50 | 130 (53.28) | 1992 (47.15) | 1 | – |
| > 50 | 114 (46.72) | 2233 (52.85) | 1.278 (0.987–1.656) | – |
| T stage | 0.000 | |||
| T1 | 25 (10.25) | 795 (18.82) | 1 | 0.000 |
| T2 | 28 (11.48) | 765 (18.11) | 1.164 (0.673–2.014) | 0.587 |
| T3 | 81 (33.20) | 1546 (36.59) | 1.666 (1.055–2.630) | 0.028 |
| T4 | 110 (45.08) | 1119 (26.48) | 3.126 (2.006–4.872) | 0.000 |
| N stage | 0.000 | |||
| N0 | 6 (2.46) | 369 (8.73) | 1 | 0.000 |
| N1 | 25 (10.25) | 1568 (37.11) | 0.981 (0.399–2.407) | 0.966 |
| N2 | 94 (38.52) | 1475 (34.91) | 3.919 (1.704–0.017) | 0.001 |
| N3 | 119 (48.77) | 813 (19.24) | 9.002 (3.928–20.629) | 0.000 |
| Plasma EBV DNA | 0.000 | |||
| Low* | 127 (52.05) | 3426 (81.09) | 1 | – |
| High** | 117 (47.95) | 799 (18.91) | 3.950 (3.038–5.137) | – |
| Group | 0.001 | |||
| CWU | 157 (64.34) | 3141 (74.34) | 1 | – |
| PET | 87 (35.66) | 1084 (25.66) | 1.606 (1.225–2.1.5) | – |
DM, distant metastasis
*Low EBV DNA level of < 14,650 copies/ml
**High EBV DNA level of ≥ 14,650 copies/ml