Fig. 2.

Effect of CT-133 on BAL fluid inflammatory cell counting and classification, oxygen saturation (SO₂) and lung weight coefficient. For acute pulmonary injury, (A) CT-133 (10 and 30 mg/kg) or Dex (1 mg/kg) were intragastrically administered 1 h before and 12 h after intratracheal LPS instillation. BAL fluid was collected 24 h after the LPS challenge to calculate the total number of cells, and the numbers of neutrophils, macrophages and lymphocytes. (B) Twenty-4 h after LPS challenge, oxygen saturation (SO₂) was measured in all mice with a Moor VMS-OXY™ monitor. (C) Twenty-4 h after LPS challenge, lung weight coefficient was measured by dividing the individual lung weight of each mouse by its body weight. ^##P < 0.01 versus NS + vehicle group; *P < 0.05, **P < 0.01 versus LPS + vehicle group. Values are expressed as mean ± S.E.M., n = 12 for each group.