Fig. 4.

Effect of CT-133 on histopathological changes in the lungs of LPS-induced ALI mice. Paraffin-embedded lung sections from each experimental group were stained with hematoxylin-eosin (H&E) for histopathological evaluation. (A) Representative images of lung tissues stained with H&E show oedema and infiltration of neutrophils and inflammatory cells. (B) Quantitative analysis of lung injury scored by two blinded pathologists with expertise in lung pathology. ^##P < 0.01 versus vehicle + vehicle group; *P < 0.05, **P < 0.01 versus LPS + vehicle group. Values are expressed as mean ± S.E.M., n = 12 for each group.