Fig. 5.

Effect of CT-133 on LPS-induced pulmonary vascular permeability. Twenty-four hours after LPS challenge, (A) albumin concentration in BAL fluid was measured using albumin determination kits. (B) Evans blue dye (50 mg/kg) was injected into the caudal vein of all mice 1 h before euthanasia. Pulmonary vascular permeability was assessed by determining the accumulation of Evans blue dye in the lung tissue. ^##P < 0.01 versus vehicle + vehicle group; *P < 0.05, **P < 0.01 versus LPS + vehicle group. Values are expressed as mean ± S.E.M., n = 12 for each group. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)