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. Author manuscript; available in PMC: 2021 Nov 27.
Published in final edited form as: ACS Biomater Sci Eng. 2019 Feb 18;5(3):1332–1342. doi: 10.1021/acsbiomaterials.8b01591

Figure 5.

Figure 5.

Pentablock copolymer (PBC) micelles did not activate innate immune cells as exhibited by cell surface markers expression and less inflammatory cytokines secretions. (A) BALB/c-derived BMDCs and (B) J774 cells at a concentration of 2.5 × 106 cells/mL were stimulated with different treatment groups (PBC micelles at the concentration of 12.5 μg/mL and LPS at 1 μg/mL) for 48 h. Flow cytometry was used to measure the cell surface marker upregulation. Cytokine secretion was evaluated from the supernatants collected after stimulation. Data is expressed as mean with standard error of mean. Statistical differences were determined using one-way ANOVA. *indicates p < 0.05, ** indicates p < 0.005 and *** indicates p < 0.0005.