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. 2021 Nov 27;18:277. doi: 10.1186/s12974-021-02323-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Difference in BIM, EIM and CC profile across COVID-19 subjects and matched controls. A BIMs including MAP2, NSE and S100B were significantly (p < 0.05) higher immediately after COVID-19 hospitalization. B sICAM1 and SVCAM1 levels were significantly higher after COVID-19 hospitalization. C Several inflammatory markers including GRO, IL10, sCD40L, IL1RA, IP10, MCP1 and TNFa were significantly higher after COVID-19. MDC and MIP1a were significantly lower after COVID-19. D Chord diagram reveals significant (p < 0.05, Fishers’ test) differences in interactions between the BIM, EM, and CCs across COVID-19 and control groups