. Author manuscript; available in PMC: 2021 Nov 27.

Published in final edited form as: J Org Chem. 2021 Aug 17;86(17):12436–12442. doi: 10.1021/acs.joc.1c01466

Table 2.

Investigation into the Cross-Coupling/Cleavage Reaction of Lactam 2a


entry	deviations from standard conditions	% yield (3a; 3b)
1	none	10;	52
2	RuPhos-Pd-G4	60;	12
3	CataCXium A-Pd-G4	13;	49
^a4	QPhos-Pd-G3	—;	20
^a5	RuPhos-Pd-G4, p-benzoquinone (10 mol%)	43;	9
^a6	w/ p-benzoquinone (10 mol%)	10;	50
^a7	K₂CO₃ instead of Cs₂CO₃	returned 2a
^a8	Phl instead of PhBr	5;	15

NMR yield based on ¹H NMR integration using 1,3,5-trimethoxybenzene as the internal standard. Reactions run on a 0.1 mmol scale.