Fig. 2.

Dynamics of Global Pneumococcal Sequence Clusters (GPSCs) among invasive isolates from children aged ≥5 years old over vaccine periods in Brazil. The number of invasive pneumococcal isolates, coloured by serotypes, is plotted by GPSC with stratification into two vaccine periods (pre-PC10 and post-PCV10) and MLST CC. Solid fill represented the VT and NVT additional PCV13 serotypes while hatched patterns represented the NVT non-PCV serotypes. The antibiotic resistance pattern to penicillin, chloramphenicol, erythromycin, cotrimoxazole, tetracycline and MDR are present for each GPSC and in the entire period studied.