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. 2021 Nov 23;15:4741–4757. doi: 10.2147/DDDT.S334421

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© 2021 Wu et al.

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Saikosaponin D attenuated the formation of F-actin and bone resorption. (A) M-CSF-dependent BMMs stimulated by RANKL were treated with SSD of different concentrations. Mature osteoclasts were stained with F-actin Staining Kit and DAPI respectively. (B) The number of osteoclasts with F-actin rings. (C) An equal number of M-CSF-dependent BMMs stimulated by RANKL were seeded on bone slices in the presence of different concentrations of SSD. After 7 days, bone resorption lacunae were observed by SEM. Bone resorption pits were highlighted with white arrows. (D) The proportion of resorption pit areas. Original magnification, × 100. Scale bar, 200 μm. Mean ± SD is used to describe the data. Above experiments were conducted independently at least 3 times. ****P <0.0001, ***P<0.001.