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. 2021 Nov 23;15:4741–4757. doi: 10.2147/DDDT.S334421

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© 2021 Wu et al.

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Saikosaponin D attenuated RANKL-induced activation of MAPKs and PI3K-AKT pathways. (A and B) SSD suppressed the phosphorylation and activation of JNK, ERK, P38, AKT and PI3K induced by RANKL. (C and D) The expressions of p‐ERK, p-JNK, p-P38, p-AKT and p-PI3K relative to total cellular proteins. (E) SSD suppressed RANKL-induced activation of NFATc1 and c-FOS. Immunoblot analyses were performed on total proteins extracted from BMMs treated with SSD and RANKL for 0, 1, 3, or 5 days. (F) The expressions of NFATc1 and c-FOS relative to β-actin. Mean ± SD is used to describe the data. Above experiments were conducted independently at least 3 times. ****P <0.0001, ***P<0.001, *P <0.05.

Abbreviation: ns, not significant.