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. 2021 Nov 23;15:4741–4757. doi: 10.2147/DDDT.S334421

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© 2021 Wu et al.

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Saikosaponin D inhibited inflammatory bone loss induced by LPS. (A) The calvarial bones were subjected to TRAP staining. The region of interest was highlighted with a red box. (B) Micro‐CT scanning and subsequent 3D reconstruction of the calvarial bones from the LPS in high‐dose SSD group, LPS with low‐dose SSD group, LPS group, and Sham group (scale bar = 1mm). The region of interest was highlighted with a red box. (C) Determination of BV/TV (bone volume/total volume). Percentage porosity and the number of pores. There were 6 randomly assigned mice in each group. Mean ± SD is used to describe the data. ****P <0.0001, ***P<0.001.