Table 4.
Multivariate Cox Regression Analysis of OS and PFS
| Characteristics | OS | PFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| KPS | 0.436 | 0.710 | ||||
| 90–100 | 1.000 | 0.668–2.548 | 1.000 | 0.5690–2.288 | ||
| 70-80 | 1.305 | 1.141 | ||||
| Differentiation | 0.74 | 0.58 | ||||
| Well/Moderate | 1.000 | 0.548–2.331 | 0 | 1.000 | 0.578–2.638 | 6 |
| Poor | 1.130 | 1.235 | ||||
| Primary tumor size | 0.130 | |||||
| ≤ 4cm | 1.000 | 0.924–1.859 | ||||
| > 4cm | 1.310 | |||||
| cTNM status | 0.03 | 0.07 | ||||
| IIIA | 1.000 | 1.038–2.204 | 1 | 1.000 | 0.958–2.181 | 9 |
| IIIB | 1.512 | 1.446 | ||||
| Response rate | 0.189 | 0.092 | ||||
| CR+PR | 1.000 | 0.885–1.856 | 1.000 | 0.944–2.155 | ||
| SD+PD | 1.282 | 1.426 | ||||
| NPS Group | 0.001 | 0.006 | ||||
| 0/1 | 1.000 | 1.326–2.981 | 1.000 | 1.182–2.721 | ||
| 2 | 1.988 | 1.793 | ||||
Abbreviations: OS, overall survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; KPS, Karnofsky performance score; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.