Table 1.

Quantitative Studies of Association Between ADR and QoL in MDR-TB Patients

Study Design	Setting	Target	HRQoL Measurement	Summary of Result	Reference
Cross sectional	Johannesburg, South Africa, February 2015-January 2018	DR-TB Patients; ≥ 18 years old (n= 149)	Short Form-36 (SF-36)	Patients with ADR experience were more likely to have lower MCS (aRR 2.24 95% CI 1.53–3.27) and PCS (aRR 1.52 95% CI 1.07–2.18).	Sineke et al, 201922
Cross sectional	Namibia, January-April 2015	MDR-TB patients in the final month or had completed the treatment within the past 3 months; aged 17–54 years (n= 36)	Short Form-8 (SF-8)	There was no significant different between patients reporting zero to two ADR (median HRQoL score = 56.8; 44.4–56.8) with those reporting three or more ADR (median HRQoL score = 55.2 (38.6–56.8); (p value = 0.34)).	Sagwa et al, 201630
Cross sectional	Belo Horizonte, Brazil. March-December 2015.	Both DR-TB and DS-TB patients, >18 years old (n= 73)	Abbreviated World Health Organization Quality of Life Questionnaire (WHOQOL-Bref)	There were significant association between the type of ADR and HRQoL in univariate analysis (p value =0.016) and in multivariate analysis (p value =0.012).	Valadares et al, 202020

Abbreviations: HRQoL, health-related quality of life; ADR, adverse drug reaction; MCS, mental component summary; PCS, physical component summary; aRR, adjusted relative risk; CI, confidence interval; DR-TB, drug resistant tuberculosis; MDR-TB, multi-drug resistant tuberculosis.