Figure 2.

Synergistic local and abscopal efficacy of intratumoral co-injections of BO-112 and the DMXAA STING agonist. (A–B) The in vivo tumor growth (mm³) for individual MC38 (A) or B16.OVA (B) tumor-bearing mice is shown for treated (upper panels) and untreated (lower panels) tumors. (C–D) The means (±SEM) of tumor size volume (mm³) for in vivo tumor progression are shown for treated (upper panel) and untreated (lower panel) MC38 (C) and B16.OVA (D) tumors. (E–F) The percentage of survival for MC38 (E) or B16.OVA (F) tumor-bearing mice is shown over time. The numbers under each graph represent the fraction of mice which achieved complete tumor regression. Data represent two independent experiments of a total of three (MC38 model) or two (B16.OVA model) experiments with five to six mice per group. Two-way analyses of variance (ANOVAs) (C–D) or log-rank (E–F) tests were used to assess significance. Significant differences are displayed for comparisons of each single-treatment group with the BO-112 +DMXAA group (**p<0.01, ***p<0.001, ****p<0.0001). DMXA, 5,6-dimethylxanthenone-4-acetic acid.