Figure 5.

Conventional type 1 dendritic cells (cDC1), endogenous expression of type I interferon receptors and STING function in the host mouse are critical for the combined local and distant effects (A–C) The average of in vivo tumor growth (mm³) is shown for treated (left panel) and untreated (right panel) tumors in BATF3 (A), IFNAR (B) or STING (C) knockout mice. (B) The percentage of survival is shown for BATF3 (D), interferon-α/β receptor (IFNAR) (E) or STING (F) knockout mice. Data are representative of two independent experiments with five to six mice per group (mean±SEM). Two-way analyses of variance (ANOVAs) (A–C) or log-rank (D–F) tests were used to assess significance. Significant differences are displayed for comparisons of each single-treatment group with the BO-112 +DMXAA group (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001). BATF3, basic leucine zipper ATF-like transcription factor 3; DMXAA, 5,6-dimethylxanthenone-4-acetic acid.