Table 2:
Time-varying values of patient characteristics at most recent measure* prior to a deprescribing event
| Characteristic | Deprescribing (54,942 person weeks) | No Deprescribing (1,506,189 person weeks) | p-value |
|---|---|---|---|
| Mean ± SD or N (%) | |||
|
| |||
| Systolic BP (mmHg) | 126 ± 16 | 131 ± 15 | <0.001 |
| Diastolic BP (mmHg) | 68 ± 8 | 70 ± 8 | <0.001 |
| Systolic BP ≥ 150 mmHg | 7.8% | 10.4% | p-for trend |
| 130–<150 mmHg | 29.1% | 39.8% | <0.001 |
| 110–<130 mmHg | 48.0% | 42.6% | |
| 90–<110 mmHg | 14.7% | 7.0% | |
| <90 mmHg | 0.3% | 0.1% | |
| Diastolic BP ≥90 mmHg | 0.7% | 1.2% | p-for trend |
| 80–<90 mmHg | 6.6% | 10.3% | <0.001 |
| 70–<80 mmHg | 31.4% | 40.1% | |
| 60–<70 mmHg | 46.1% | 39.4% | |
| <60 mmHg | 15.1% | 9.0% | |
| ADL Score = 0 | 6.7% | 7.3% | p-for trend |
| 1–14 | 42.9% | 42.4% | 0.90 |
| 15–27 | 46.3% | 45.5% | |
| 28 | 4.1% | 4.8% | |
| Intact Cognitive Function Score (1) | 18.3% | 21.6% | p-for trend |
| Mildly impaired (2) | 32.3% | 30.7% | <0.001 |
| Moderately impaired (3) | 24.9% | 24.6% | |
| Severely impaired (4) | 24.6% | 23.2% | |
| Fall in last 30 days | 23.3% | 21.4% | <0.001 |
| eGFR (mL/min/1.73m2) | 64 ± 34 | 69 ± 33 | <0.001 |
| Albumin to Creatinine Ratio† (μg/mg) | 33 (6, 167) | 24 (5, 126) | 0.001 |
| Creatinine (mg/dL) | 1.57 ± 1.73 | 1.38 ± 1.60 | <0.001 |
| CO2 (mEq/L) | 27.2 ± 4.1 | 27.4 ± 3.8 | <0.001 |
| Albumin (g/dL) | 3.16 ± 0.58 | 3.30 ± 0.54 | <0.001 |
| Triglycerides (mg/dL) | 120 ± 76 | 126 ± 80 | <0.001 |
| Total Cholesterol (mg/dL) | 135 ± 35 | 140 ± 35 | <0.001 |
| LDL-Cholesterol (mg/dL) | 73 ± 29 | 75 ± 29 | <0.001 |
| HDL-Cholesterol (mg/dL) | 38.8 ± 12.7 | 39.1 ± 12.3 | <0.001 |
| HbA1C (%) | 6.6 ± 1.3 | 6.6 ± 1.2 | 0.11 |
| Glucose (mg/dL) | 129 ± 51 | 127 ± 52 | <0.001 |
| BUN (mg/dL) | 31 ± 17 | 26 ± 14 | <0.001 |
| Sodium (mEq/L) | 138.0 ± 5.1 | 138.5 ± 4.9 | <0.001 |
| Potassium (mEq/L) | 4.28 ± 0.49 | 4.25 ± 0.45 | <0.001 |
| Top Quartile of Medication/Supplement Use | 21.1% | 27.4% | <0.001 |
| 2 Antihypertensive medications | 32.8% | 34.5% | p-for trend <0.001 |
| 3 Antihypertensive medications | 19.6% | 15.7% | |
| 4+ Antihypertensive medications | 6.5% | 10.5% | |
*
This analysis used the deprescribing event as the index time and looked backwards in time at the most recent value of the measure of interest.
†
median (IQR)
BP = blood pressure; ADL = activities of daily living; eGFR = estimated glomerular filtration rate; CO2 = carbon dioxide; LDL = low density lipoprotein; HDL = high density lipoprotein; HbA1C = hemoglobin A1C, BUN = blood urea nitrogen