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. 2021 Nov 27;7:368. doi: 10.1038/s41420-021-00756-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Mice were injected shNC, shMALAT1, CCl4 in combination with shNC (shNC + CCl4), or CCl4 in combination with sh-MALAT1 (shMALAT1 + CCl4) (n = 10/group). Expressions of F4/80 and Ly6c proteins were detected by immunohistochemistry (A) and by western blot (B) in liver tissues from indicated groups. C The expressions of MALAT1, F4/80, Ly6c, IL-6, and iNOS were examined by RT-qPCR. D The expressions of pyroptosis-related markers, NLRP3, pro-caspase-1, Caspase-1, and GSDMD-N from liver tissues of indicated groups were examined by western blot. E The levels of IL-1β and IL-18 in the liver tissues were measured by ELISA from indicated groups. *P < 0.05, **P < 0.01, ***P < 0.001.