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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Clin Toxicol (Phila). 2021 May 28;60(2):221–230. doi: 10.1080/15563650.2021.1925686

Figure 1.

Figure 1.

Metabolites involved with glutathione metabolism and urea cycle associated with ALT class: (A) four metabolites identified as being significant and well modeled using ASCA to look at ALT class and time in a multivariate analysis using SPE and leverage as criteria to determine significance. (B) Key to interpret ASCA matched spatially and by color to plot in A. (C) Metabolites identified as significant in ASCA related to glutathione metabolism. (D) Metabolites identified as significant in ASCA related to urea cycle. *Significance determined by high leverage and low SPE (see Supplemental Table 2 for details). ALT elevation, n = 7; no ALT elevation, n = 7.