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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Can J Ophthalmol. 2021 May 28;57(4):217–227. doi: 10.1016/j.jcjo.2021.04.025

Table 1:

Use of DWI in differentiating orbital lesions

Key study endpoint Author Year of publication DWI technique used Inclusion ADC cutoff value (x 10−3 mm2/s) Sensitivity (%) Specificity (%)
Identification of lymphoma Haradome et al.28 2014 Unspecified Lymphoma (29)

Benign orbital lymphoproliferative disorder (18)		 < 0.612 94.1 93.3
Politi et al.27 2010 Unspecified Lymphoma (38)

Normal orbit (18)		 < 0.775 96 93
Primary non-lymphoma neoplasm (20)
Benign vascular lesion (15)
Benign inflammatory lesion (12) Metastasis (11)
Sepahdari et al.34 2010 EPI Lymphoma (6)

Inflammatory pseudotumor (10)		 < 1.0 100 100
Differentiation of malignant vs. benign lesions ElKhamary et al.61 2018 EPI < 0.8 86.7 66.9
Razek et al.29 2011 EPI Malignant (22): Non-Hodgkin lymphoma (6)
Metastasis (5)
Rhabdomyosarcoma (4)
Adenocarcima (2)
Other (5)

Benign (25):
Pseudotumor (5)
Lymphangioma (3)
Pleomorphic adenoma
(3) Schwanoma
(3) Venous malformation (3)
Other (8)		 < 1.15 95 91
Sepahdari et al.34 2010 EPI Malignant (16)

Benign (31)

(otherwise unspecified)		 < 1.0 63 84

DWI: Diffusion-weighted imaging

ADC: Apparent diffusion coefficient

EPI: Echo-planar imaging