Table 3.
Aortic PWV x APOE-ε4 x Time Interactions and Stratifications by APOE-ε4 Status with Longitudinal Magnetic Resonance Imaging Outcomes
| β | 95 % CI | p-value | FDR p-value | |
|---|---|---|---|---|
|
APOE-ε4 Status Interaction Gray
Matter Neuroimaging Markers
((mm
3
/year)/(m/s))
| ||||
| Total gray matter | −164.8 | −903.8, 574.2 | 0.66 | 0.86 |
| Frontal gray matter | −14.69 | −384.8, 355.4 | 0.94 | 0.94 |
| Temporal gray matter | −99.42 | −232.9, 34.02 | 0.14 | 0.47 |
| Parietal gray matter | −19.15 | −187.7, 149.4 | 0.82 | 0.94 |
| Occipital gray matter | −29.49 | −111, 51.97 | 0.48 | 0.69 |
| Hippocampus | −4.45 | −13.55, 4.66 | 0.34 | 0.55 |
| Inferior lateral ventricle | 13.32 | −2.84, 29.47 | 0.11 | 0.46 |
| APOE-ε4 Status Interaction WMH Neuroimaging Markers ((mm 3 /year)/(m/s)) | ||||
| Total WMH | −138.9 | −355.8, 78.08 | 0.21 | 0.54 |
| Frontal WMH | −61.02 | −180.7, 58.65 | 0.32 | 0.55 |
| Temporal WMH | −27.16 | −50.30, −4.02 | 0.02* | 0.14 |
| Parietal WMH | −40.71 | −111.9, 30.53 | 0.26 | 0.55 |
| Occipital WMH | 2.50 | −38.78, 43.78 | 0.91 | 0.94 |
|
APOE-ε4 Carriers Gray Matter Neuroimaging Markers ((mm 3 /year)/(m/s)) | ||||
| Total gray matter | −485.4 | −1190, 219.6 | 0.18 | 0.37 |
| Frontal gray matter | −106.6 | −448.2, 234.9 | 0.54 | 0.69 |
| Temporal gray matter | −132.1 | −268.4, 4.21 | 0.06 | 0.26 |
| Parietal gray matter | −100.1 | −252.8, 52.52 | 0.20 | 0.37 |
| Occipital gray matter | −69.59 | −152.9, 13.74 | 0.10 | 0.30 |
| Hippocampus | −7.97 | −17.96, 2.01 | 0.12 | 0.30 |
| Inferior lateral ventricle | 21.50 | −0.92, 43.92 | 0.06 | 0.26 |
| APOE-ε4 Carriers WMH Neuroimaging Markers ((mm 3 /year)/(m/s)) | ||||
| Total WMH | −58.09 | −320.3, 204.1 | 0.66 | 0.69 |
| Frontal WMH | −35.55 | −172.9, 101.8 | 0.61 | 0.69 |
| Temporal WMH | −6.98 | −23.84, 9.87 | 0.42 | 0.67 |
| Parietal WMH | −19.05 | −105.3, 67.19 | 0.66 | 0.69 |
| Occipital WMH | 8.11 | −31.63, 47.85 | 0.69 | 0.69 |
|
APOE-ε4 Non-carriers Gray Matter Neuroimaging Markers ((mm 3 /year)/(m/s)) | ||||
| Total gray matter | −89.79 | −465.9, 286.4 | 0.64 | 0.82 |
| Frontal gray matter | 15.46 | −183.9, 214.8 | 0.88 | 0.88 |
| Temporal gray matter | −28.64 | −84.82, 27.54 | 0.32 | 0.51 |
| Parietal gray matter | −30.13 | −123.3, 63.09 | 0.53 | 0.76 |
| Occipital gray matter | −25.96 | −62.2, 10.29 | 0.16 | 0.35 |
| Hippocampus | −3.48 | −6.98, 0.02 | 0.05 | 0.33 |
| Inferior lateral ventricle | 4.88 | −2.07, 11.83 | 0.17 | 0.35 |
| APOE-ε4 Non-carriers WMH Neuroimaging Markers ((mm 3 /year)/(m/s)) | ||||
| Total WMH | 70.26 | −20.74, 161.3 | 0.13 | 0.35 |
| Frontal WMH | 10.10 | −40.96, 61.17 | 0.70 | 0.82 |
| Temporal WMH | 23.95 | 11.59, 36.32 | <0.001* | 0.003 |
| Parietal WMH | 19.73 | −9.78, 49.23 | 0.19 | 0.35 |
| Occipital WMH | 2.08 | −16.20, 20.37 | 0.82 | 0.88 |
Note. Analyses performed on n=278 participants and subsequently stratified by APOE-ε4 status for n=97 APOE-ε4 positive participants and n=181 APOE-ε4 negative participants. The interaction term was aortic PWV x time x APOE-ε4 status. Models were adjusted for age, sex, race/ethnicity, education, APOE-ε4 status, and Framingham Stroke Risk Profile (excluding points assigned for age). APOE-ε4, apolipoprotein E ε4 allele. CI, confidence interval; FDR p-value, false discovery rate corrected p-value. For the APOE-ε4 Status interaction model, the parameter estimates (β) are for the PWV x APOE-ε4 x time interaction term and is interpreted as the difference in annual changes of outcomes between APOE-ε4 positive participants and APOE-ε4 negative participants associated with one unit change in PWV (per 1 m/s). For stratified models by APOE-ε4 status, the parameter estimates (β) are for the PWV x time interaction term and is interpreted as the annual changes of outcomes associated with one unit change in PWV (per 1 m/s).
Meets the a priori significance threshold of 0.05