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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Nat Neurosci. 2021 Apr 19;24(6):886–896. doi: 10.1038/s41593-021-00841-5

Extended Data Fig. 2. Testing the multimodal recording setup using Neuro-FITM and standard silicon probes under both the wide-field and 2-photon imaging systems.

Extended Data Fig. 2

a, A picture of the probes tested in the multimodal recording setup. b, Pictures of the side view under the 2-photon imaging system. Neuro-FITM can be completely bent to the side as shown with the blue dashed line. Both the Neuronexus probes and the Neuropixel probe prevent the lowering of microscope objective (total rigid part indicated by red double arrow). The right column are the 2-photon images of the array surface, showing the thin Au wires, the boundary of the array substrate, and the penetration point. c, Pictures of the experimental setup (top), the zoom-in side view (middle), and the field of view (bottom) under wide-field imaging system, showing the blocking of field of view (Neuronexus probes) and preventing the lowering of microscope objective (Neuropixel probe). Wide-field image shows that mostly transparent Neuro-FITM does not block the field of view or generate shadows.