1. Diabetic foot management guidelines and levels of evidence.

Guideline and management recommendations	Level of evidence (According to Oxford Centre for Evidence‐based Medicine ‐ Levels of Evidence (March 2009))	Glycaemic target
National Health and Medical Research Council (NHMRC):  Prevention, identification and management of foot complications in diabetes mellitus 2011 Local sharp debridement Topical hydrogel dressings Pressure reduction Offloading Removable offloading Multidisciplinary care management Negative pressure therapy Hyperbaric oxygen Larval therapy Cultured skin equivalents Skin grafting Note: as per NHMRC levels of evidence	Expert opinion Grade B Grade B Grade B Expert opinion Grade C Grade B Grade B Grade C Grade B Grade D	Not reported
National Clearinghouse Guidelines  2011 Debridement with multidisciplinary team Off‐loading of foot ulcers Pressure relieving support surfaces Negative pressure wound therapy Avoid the use of: dermal or skin substitutes electrical stimulation therapy autologous platelet‐rich plasma gel regenerative wound matrices and dalteparin growth factors hyperbaric oxygen therapy	Not reported	HbA1c < 7% Level B
National Clearinghouse guidelines 2012 (treatment of neuropathic wounds) Assessment by a wound expert	Grade C
National Health Service (NHS): Type 2 diabetes: prevention and management of foot problems 2004 Urgent attention within 24 hours Multidisciplinary treatment Multidisciplinary team comprising a podiatrist, orthotists, specialised nurse, diabetologist; with unhindered access to suites for managing major wounds, antibiotic administration, urgent inpatient facilities, community nursing, microbiology and diabetic services Prompt Revascularisation Intensive systemic antibiotic therapy Appropriate wound dressing Close monitoring and regular wound dressing changes Debridement of dead tissue Total contact casting Hyperbaric oxygen, cultured human dermis, topical ketanserin or growth factors Foot care reminders	Grade D Grade D Grade D Grade D Grade C Grade D Grade D Grade B Grade B Grade D Grade B	Not reported
National Health Service (NHS): 2011 National Institute for Health and Care Excellence (NICE) clinical guideline. Developed by the Centre for Clinical Practice at NICE: Diabetic foot problems: inpatient management of diabetic foot problems Debridement Wound dressings Offloading Antibiotics for infection Timing for surgical management.	Not reported	Not reported
2012 International Working Group on Diabetic Foot (IWGDF): Global guideline for type 2 diabetes Local wound care Relief of pressure Treatment of infection Metabolic control Restoration of skin perfusion	Not reported	< 8 mmol/l
Australian diabetic foot Network: Management of diabetes related foot ulceration ‐ a clinical update Debridement Dressing selection Pressure offloading Management of infection Glycaemic control Multidisciplinary care	Not reported	Not reported
American College of Foot and Ankle surgeons 2006 (revision): Diabetic foot disorders – a clinical practice guideline Debridement Pressure offloading Treatment of infection Optimise metabolic perturbations	Not reported	Not reported
Scottish Intercollegiate Guidelines Network (SIGN) Guidelines 2010 Referral to a multidisciplinary care team Total contact casts for unilateral ulcers Irremovable walkers Negative pressure wound therapy Arterial reconstruction for those who require it	Grade C Grade B Grade B Grade B Grade B	Not reported
American Diabetes Association Standards of Medical Care in Diabetes 2012 Multidisciplinary approach Foot ulcers and wound care may require care by a podiatrist, orthopedic or vascular surgeon, or rehabilitation specialist experienced in the management of individuals with diabetes	Grade B Not reported	As per position Statement for optimal Control