Table 3.

MIC₉₀ and range of MICs^a against biothreat bacterial pathogens

Compounds	Media	B. pseudomallei	B. mallei	Y. pestis
GT-1	CAMHB	≤0.03 (≤0.03-0.5)	32 (4–32)	2 (0.12–4)
	ID-CAMHB	0.12 (≤0.03–0.12)	8 (2–16)	0.5 (≤0.03–0.5)
GT-1/GT-055 (2:1)	CAMHB	≤0.03/≤0.015 (≤0.03/≤0.015–0.25/0.125)	8/4 (2/1–16/8)	2/1 (0.12/0.06–2/1)
	ID-CAMHB	0.25/0.125 (≤0.03/≤0.015–8/4)	4/2 (2/1–8/4)	0.5/0.25 (0.06/0.03–1/0.5)
GT-1 + GT-055 (4 μg/ml)	CAMHB	≤0.03/4 (≤0.03/4)	8/4 (1/4–16/4)	1/4 (≤0.03/4–2/4)
	ID-CAMHB	0.06/4 (≤0.03/4–4/4)	2/4 (0.5/4–4/4)	0.12/4 (≤0.03/4–0.25/4)
GT-055	CAMHB	>32 (>32)	>32 (32–>32)	>32 (8–>32)
	ID-CAMHB	>32 (>32)	>32 (>–32)	>32 (2–>32)
DOX	CAMHB	2 (0.25–2)	0.12 (≤0.015–0.25)	1 (0.12–1)
	ID-CAMHB	1 (0.5–>32)	0.25 (≤0.015–0.5)	1 (0.12–2)

^aMIC (μg/ml) of GT-1 or GT-055 or GT-1/GT-055 in combination