Skip to main content
. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Semin Cancer Biol. 2021 Jun 5;76:61–73. doi: 10.1016/j.semcancer.2021.06.003

Figure 7.

Figure 7.

RARα-retinoid agonist and RXRα interact with NRF2 and decrease NRF2-target gene transcription. (A) Recruitment of transactivation machinery after NRF2/sMAF binding to ARE leads to transcription of NRF2-target genes. (B) NRF2-RARα-retinoid agonist interaction decreases NRF2 binding to AREs and reduces NRF2-target gene transcription. (C) NRF2-RXRα interaction does not prevent binding to AREs, but decreases BCP/RNA polymerase II loading, ultimately diminishing transactivation and decreasing NRF2-target gene transcription.