Table 1:
Patient characteristics.
| Characteristics | Median, IQR, or Frequency (%) n=100 (All) |
Median, IQR, or Frequency (%) n=45 (Non-dilated group) |
Median, IQR, or Frequency (%) n=55 (Dilated group) |
|---|---|---|---|
| Age (years) at index endoscopy | 37.4 (27 to 46) | 32.6 (23.5 to 45.1) | 38.4 (31.1 to 46.7) |
| Age (years) at diagnosis a | 32.0 (22 to 41) | 30.0 (19.0 to 39.0) | 35.5 (28.0 to 41.0) |
| Age (years) at first endoscopy b | 31.0 (20 to 39) | 30.0 (19.5 to 41.0) | 32.2 (24.0 to 39.0) |
| Age (years) at first symptom onset c | 23.5 (15 to 34) | 22.2 (16.0 to 38.0) | 26.2 (12.6 to 33.8) |
| Disease duration (years) d | 9.7 (4 to 19) | 7.1 (3.8 to 12.4) | 10.2 (7.1 to 22.7) |
| Diagnostic delay (years) e | 4.0 (1 to 13) | 3.0 (0.9 to 29.9) | 8.9 (0.1 to 40.0) |
| Male | 61 (61.0%) | 25 (55.6%) | 36 (65.5%) |
| White | 94 (94.0%) | 42 (93.3%) | 52 (94.5%) |
| Peak eos/hpf | 18.0 (2 to 51) | 18.0 (2.0 to 48) | 19.0 (2.0 to 52) |
| EoEHSS (grade+stage) | 0.7 (0.3 to 0.9) | 0.7 (0.3 to 0.9) | 0.6 (0.3 to 1.0) |
| EREFS (proximal+distal) | 5 (2 to 8) | 3 (2 to 7) | 5 (3 to 9) |
| EREFS (proximal) | 2 (1 to 4) | 2 (1 to 3) | 3 (1 to 4) |
| EREFS (distal) | 3 (1 to 5) | 2 (1 to 3) | 3 (2 to 5) |
| RS (proximal+distal) | 2 (0 to 4) | 1 (0 to 6) | 3 (0 to 8) |
| RS (proximal) | 1 (0 to 2) | 1 (0 to 3) | 1 (0 to 4) |
| RS (distal) | 1 (0 to 2) | 0 (0 to 3) | 2 (0 to 4) |
| EEF (proximal+distal) | 3 (1 to 4) | 3 (0 to 8) | 3 (0 to 8) |
| EEF (proximal) | 1 (0 to 2) | 1 (0 to 3) | 1 (0 to 4) |
| EEF (distal) | 2 (0 to 3) | 1 (0 to 5) | 2 (0 to 5) |
| EEsAI PRO score | 27 (12 to 42) | 27 (12 to 43) | 27 (12 to 39) |
| Frequency of trouble swallowing | |||
| Never | 43 (43.0%) | 18 (40.0%) | 25 (45.5%) |
| 1–3 times/week | 39 (39.0%) | 17 (37.8%) | 22 (40.0%) |
| 4–6 times/week | 13 (13.0%) | 6 (13.3%) | 7 (12.7%) |
| Daily | 5 (5.0%) | 4 (8.9%) | 1 (1.8%) |
| Pain when swallowing | 17 (17.0%) | 8 (17.8%) | 9 (16.4%) |
| Visual dysphagia question | 1.7 (0 to 6) | 2.1 (0.4 to 3.3) | 1.4 (0 to 3.3) |
| Avoidance, modification, slow eating (median (range)) | 1.7 (0 to 6) | 1.8 (0.3 to 3.2) | 1.5 (0.5 to 2.9) |
| EoE-QoL-A score | 27.0 (15 to 48) | 27.0 (15.0 to 51.0) | 26.5 (16.0 to 47.5) |
| Impact of diet/eating | 6.0 (3 to 10) | 7.0 (3.0 to 11.0) | 5.0 (3.0 to 9.0) |
| Social impact | 4.0 (1 to 8) | 4.0 (1.0 to 8.0) | 3.0 (0.0 to 8.0) |
| Emotional impact | 7.0 (3 to 13) | 7.0 (3.0 to 13.0) | 7.0 (3.0 to 11.0) |
| Disease anxiety | 6.0 (3 to 12) | 6.0 (3.0 to 11.0) | 7.0 (4.0 to 12.0) |
| Swallowing anxiety | 4.0 (1 to 6) | 4.0 (1.0 to 8.0) | 4.0 (2.0 to 6.0) |
| Anti-eosinophil therapy (at index endoscopy) | |||
| None | 4 (4.0%) | 1 (2.2%) | 3 (5.5%) |
| Monotherapy with diets | 21 (21.0%) | 11 (24.4%) | 10 (18.2%) |
| Monotherapy with proton-pump inhibitors | 11 (11.0%) | 5 (11.1%) | 6 (10.9%) |
| Monotherapy with swallowed topical corticosteroids | 28 (28.0%) | 14 (31.1%) | 14 (25.5%) |
| Mixed treatments | 36 (36.0%) | 14 (31.1%) | 22 (40.0%) |
| Dilation | 55 | NA | 55 |
| ≤1 year prior index endoscopy | 15 (15%) | NA | n=15 Median time (years) from dilation date to index endoscopy, IQR, range 0.59 (0.40 to 0.86), 0.11 to 0.996 |
| >1 year prior to index endoscopy | 40 (40%) | NA | n=40 Median time (years) from dilation date to index endoscopy, IQR, range 3.49 (1.95 to 4.11), 1.05 to 19.3 |
Data available in 39/45 non-dilated and 50/55 dilated patients.
Data available in 44/45 non-dilated and 53/55 dilated patients.
Data available in 38/45 non-dilated and 44/55 dilated patients.
The disease duration is defined as the time interval between the first symptom onset and index endoscopy (data available in 38/45 non-dilated and 44/55 dilated patients).
The diagnostic delay is defined as the time interval between the first symptom onset and diagnosis (data available in 32/45 non-dilated and 41/55 dilated patients).
Abbreviations: EEsAI, eosinophilic esophagitis activity index; eos/hpf, esophageal eosinophilia per high-power field; EoE-QoL-A, adult eosinophilic esophagitis-specific quality of life; EREFS, endoscopic reference score; IQR, interquartile range; RS, rings and stricture score.