Table 2.
Studies of medication for opioid use disorders in transition-age youth: outcome data.
| Author, year | Arm 1 | Arm 2 | Outcome | Follow-up (months) | Arm 1 |
Arm 2 |
Effect (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| N | Outcome | N | Outcome | ||||||
| Marsch, 2005 | BUP + CBT + CM | Clonidine + CBT + CM | Abstinence (n, %) | 1 | 18 | 12 (64%) | 18 | 6 (32%) | OR 4.0 (1.0, 16.0) |
| Woody, 2008 | BUP-NAL 12-wk + CBT | BUP-NAL 2-wk + CBT | Negative urine screens (n, %) | 1 | 74 | 16 (74%) | 78 | 19 (36%) | OR 7.1 (2.9, 17.3) |
| Negative urine screens (n, %) | 2 | 74 | 22 (77%) | 78 | 25 (46%) | OR 5.1 (2.0, 12.8) | |||
| Negative urine screens (n, %) | 3 | 74 | 25 (57%) | 78 | 25 (49%) | OR 1.8 (0.8, 4.2) | |||
| Gonzalez, 2015 | BUP-NAL + MEM 30 mg + CBT | BUP-NAL + MEM 15 mg + CBT | Abstinence (n, %) | 3 | 28 | 23 (82%) | 27 | 9 (32%) | OR 9.2 (2.6, 32.3) |
| BUP-NAL + MEM 30 mg + CBT | BUP-NAL + placebo + CBT | Abstinence (n, %) | 3 | 28 | 23 (82%) | 32 | 10 (30%) | OR 9.2 (2.7, 31.5) | |
| BUP-NAL + MEM 15 mg + CBT | BUP-NAL + placebo + CBT | Abstinence (n, %) | 3 | 27 | 9 (32%) | 32 | 10 (30%) | OR 0.8 (0.3, 2.3) | |
| Marsch, 2016 | BUP-NAL 8-wk + CBT + MI + PE + CM | BUP-NAL 4-wk + Placebo + CBT + MI + PE + CM | Abstinence (Mean % negative urine screens per patient over 28 days, 95% CI) | 2 | 25 | 34.6 (23.2, 50.0) | 28 | 17.2 (5.8, 28.6) | Cohen’s d 0.57 (0.02, 1.13) |
Note. Bold font indicates statistical significance. Abbreviations: BUP = buprenorphine; BUP-NAL = buprenorphine-naloxone; OR = odds ratio; CI = confidence interval; CBT = cognitive behavioral therapy; CM = contingency management; PE = psychoeducation; MI = motivational interviewing.