Table 1.
Comparison of ABR frequency in plasmids and chromosomes. The number of ABR genes having a bias towards plasmids or chromosomes according to the resistance mechanism classification (using Fisher's exact test in contingency analysis, α = 0.05 and correction for multiple comparisons with false discovery rate (FDR) [38]). No bias to the chromosome was found in ABR genes for antibiotic target protection and replacement (marked with ‘—’).
| genus | antibiotic efflux |
antibiotic inactivation |
antibiotic target alteration |
antibiotic target protection |
antibiotic target replacement |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| chromosome | plasmid | chromosome | plasmid | chromosome | plasmid | chromosome | plasmid | chromosome | plasmid | |
| Escherichia | 40 (74%) | 14 (26%) | 3 (2%) | 126 (98%) | 10 (50%) | 10 (50%) | — | 13 (100%) | — | 17 (100%) |
| Klebsiella | 14 (50%) | 14 (50%) | 3 (3%) | 100 (97%) | 8 (40%) | 12 (60%) | — | 11 (100%) | — | 13 (100%) |
| Salmonella | 20 (61%) | 13 (39%) | 4 (5%) | 74 (95%) | 5 (38%) | 8 (62%) | — | 9 (100%) | — | 13 (100%) |