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. 2021 Nov 24;14:6191–6221. doi: 10.2147/JIR.S332705

Figure 2.

Figure 2

SARS-CoV-2-induced signaling pathways. Diagram of the SARS-CoV-2-mediated p38/MAPK, Rho/Rock, and casein kinase II signaling pathways involved mainly in the viral replication. The p38/MAPK pathway executes a vital role in cell proliferation while the Rho/Rock, and casein kinase II signaling pathways are implicated in the cytoskeleton reorganization of normal cells. The Rho/Rock signaling is reduced upon infection.