Figure 1.

LasR mutation is associated with low elastase producing clinical isolates. The genomes of 23 high elastase producing and 24 no/low elastase producing PA ICU respiratory isolates were sequenced, and sequencing reads were aligned to the lasR and lasI reference gene sequences from PA reference strain PA14. Mutations were determined using Breseq. Statistical analysis was completed using Fisher exact test. Note that LasR regulates LasB, or Pseudomonas elastase.