Table 2.
Clinical Characteristics of ICU Patients With Low vs High Elastase Producers
| ICU Patient Characteristics | Total N = 238 |
Low Elastase n = 134 |
High Elastase n = 104 |
P |
|---|---|---|---|---|
| Age, median (IQR) | 63 (55-72) | 61 (48-70) | 66 (56-73) | .02 |
| Male, No. (%) | 138 (58.0) | 77 (57.5) | 61 (58.7) | .90 |
| Race, No. (%)a | .02 | |||
| White | 189 (79.4) | 106 (79.1) | 83 (79.8) | |
| Black | 32 (13.5) | 12 (15.7) | 11 (10.6) | |
| Asian | 5 (2.1) | 0 | 5 (4.8) | |
| Unknown | 12 (5.0) | 7 (5.2) | 5 (4.8) | |
| mSOFA score,b median (IQR) | 6 (4-8) | 6 (4-8) | 6 (4-9) | .08 |
| CCI, median (IQR) | 3 (1-5) | 2 (1-5) | 3 (1-4) | .79 |
| CCI score, No. (%) | .61 | |||
| 0 | 28 (11.8) | 14 (10.5) | 14 (13.5) | |
| 1 | 35 (14.7) | 22 (16.4) | 13 (12.5) | |
| ≥2 | 175 (73.5) | 98 (73.1) | 77 (74.0) | |
| Sample collection day,c median (IQR) | 2 (1-6) | 2 (0-6) | 2 (1-6) | .34 |
| ICU LOS,c median (IQR), d | 18 (8-34) | 19 (9-37) | 14 (7-31) | .03 |
| Mechanical ventilation, No. (%) | 184 (77.3) | 101 (75.4) | 83 (79.8) | .44 |
| HHFNC, No. (%) | 11 (4.6) | 3 (2.2) | 8 (7.8) | .06 |
| Bloodstream infection, No. (%) | 32 (13.5) | 14 (10.5) | 18 (17.3) | .13 |
| 30-d mortality,c No. (%) | 81 (34.0) | 38 (28.4) | 43 (41.4) | .04 |
| 90-d mortality,c No. (%) | 112 (47.1) | 59 (44.0) | 53 (51.0) | .30 |
238 ICU patients demonstrated a respiratory culture growing P aeruginosa. Elastase and protease activity were normalized to a research PA reference strain (PA14) and reported as % elastase activity. Low (0-50%); High (>50%). P values ≤ .05 are significant and are shown in bold. IQR = interquartile range; mSOFA = modified sequential organ failure assessment score; CCI = Charlson Co-morbidity Index; HHFNC = heated high-flow nasal canula oxygen
Race P value analysis excludes unknown race category.
Modified SOFA score calculated with neurologic score equal to 0; therefore, maximum score is 20.
Sample collection date, ICU length of stay (LOS), and 30-d and 90-d mortality were calculated from the index ICU admission date.