Table 3.
Association of PA Pathogen Characteristics and Mortality
| PA Pathogen Characteristics, N = 238 |
30-d Mortality |
90-d Mortality |
||
|---|---|---|---|---|
| Unadjusted OR (95% CI) |
Adjusteda OR (95% CI) |
Unadjusted OR (95% CI) |
Adjustedb OR (95% CI) |
|
| Elastase activity, per SD | 1.38 (1.05-1.82) | 1.39 (1.05-1.83) | 1.27 (0.97-1.66) | 1.26 (0.96-1.66) |
| Protease activity, per SD | 1.37 (1.05-1.78) | 1.34 (1.02-1.76) | 1.15 (0.89-1.48) | 1.07 (0.81-1.42) |
| Biofilm production,c per SD | 1.13 (0.87-1.47) | 1.11 (0.85-1.45) | 1.11 (0.85-1.44) | 1.03 (0.78-1.36) |
| MDR/XDRc | 1.09 (0.68-1.74) | 0.89 (0.48-1.65) | 1.26 (0.81-1.95) | 1.18 (0.64-2.15) |
| Polymicrobiald | 0.49 (0.30-0.78) | 0.60 (0.33-1.09) | 0.57 (0.37-0.87) | 0.69 (0.38-1.23) |
A logistic regression model was used to determine the association between PA pathogen factors and 30-d and 90-d mortality from time of index ICU admission. CCI = Charlson Co-morbidity Index; MDR = multidrug-resistant; mSOFA = modified sequential organ failure assessment score; XDR = extensively drug resistant
a
The 30-d mortality model was adjusted for age, sex and mSOFA.
b
The 90-d mortality model was adjusted for age, sex, mSOFA, and CCI. P < .05 are in bold.
c
n = 236 for Biofilm production, n = 234 for MDR/XDR.
d
n = 235 for polymicrobial.