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The potential beneficial effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors, such as dapagliflozin, on heart failure-related outcomes and patient-reported quality of life, independent of body mass index. SGLT2 inhibitors may exert their beneficial effects by improving fitness, volume status (without activating the nenin-angiotensin-aldosterone system), and metabolic flexibility, in addition to other factors. CRF, cardiorespiratory fitness; CVD, cardiovascular disease.
