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. 2021 Nov 26;219(1):e20210789. doi: 10.1084/jem.20210789

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© 2021 Guo et al.

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Figure S1. — AZD1775 activates immunogenic response and IFN pathway. (A) Kaplan–Meier survival curves according to different IFN pathway gene set expressions of ovarian cancer in TCGA. (B) ELISA detection of IFN-β and IFN-λ3 levels in the OV90 and OV2008 cell supernatant treated with AZD1775 or DMSO for 72 h (n = 2; three independent experiments). (C) Heatmap of qPCR quantification of selected genes differentially expressed in ID8 cells treated with DMSO or AZD1775 for 48 h (n = 3). (D) HALLMARK-IFN–enriched pathways were enriched with GSEA analysis in OV90 cells treated with AZD1775 (n = 3). (E) Heatmap of IFN pathway genes analyzed by RNA-seq in OV90 cells after treatment with 800 nM AZD1775 or DMSO for 48 h (n = 3). (F) ELISA detection of CXCL10 levels in OV90 cells treated with AZD1775 or DMSO for 72 h (n = 2; three independent experiments). *, P < 0.05; **, P < 0.01; ***, P < 0.001, as determined by log-rank test (A) and unpaired t test (B and F). P-val, P value; FDR q, false discovery rate p-value.