Figure 3. Quantitative parameters of ultrasonic vocalizations (USVs) in female mice.
Administration of flurothyl seizures significantly increased USV quantity compared to control mice. In addition, rapamycin treatment in female mice resulted in significantly reduced USV quantity when compared to all other treatment groups (A). Seizures had no effect on the average duration of USVs, however, rapamycin-treated male mice emitted USVs of significantly reduced duration compared to minocycline-treated mice (B). No significant effects were detected in the average peak frequency (C), average fundamental frequency (D), or average peak amplitude (E) of USVs in female mice. Data are expressed as mean ± standard error of the mean (SEM), * p < 0.05. Differences in lettering indicate significance between groups at the level of p < 0.05.
