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. Author manuscript; available in PMC: 2022 Jul 23.
Published in final edited form as: Behav Brain Res. 2021 Apr 25;410:113317. doi: 10.1016/j.bbr.2021.113317

Figure 6. Hippocampal proinflammatory cytokine expression in male mice.

Figure 6.

Seizures did not significantly increase the expression of IL-1β, IL-6, or TNFα in male mice (A-C). A significant effect of treatment was detected for IL-1β, with minocycline-treated mice or those that received the combined treatment having significantly increased expression compared to mice that received rapamycin or saline (A). A significant effect of treatment was detected for IL-6, with mice that received minocycline or the combined treatment having significantly higher expression levels compared to saline-treated mice, along with rapamycin-treated mice having reduced IL-6 expression compared to mice that received the combined treatment (B). A significant effect of treatment was also detected for TNFα, however, no individual treatment group differences were detected (C). Gene expression measurements on individual samples were performed in triplicate. Data are expressed as mean ± standard error of the mean (SEM). Differences in lettering indicate significance between groups at the level of p < 0.05.