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. Author manuscript; available in PMC: 2022 Jul 23.
Published in final edited form as: Behav Brain Res. 2021 Apr 25;410:113317. doi: 10.1016/j.bbr.2021.113317

Figure 8. Hippocampal expression of mTOR signaling proteins in male mice.

Figure 8.

Seizures significantly increased p70S6K expression levels compared to controls (A). No effect of seizure administration or treatment was detected for S6 (B). Mice that received rapamycin or the combined treatment had significantly downregulated levels of pS6(235,236) (C), % total pS6(235,236) (D), pS6(240,244) (E), or % total pS6(240,244) (F). There was no effect of seizures or treatment on Akt (G) or % total pAkt (I) expression levels. There was a significant effect of treatment for pAkt, with those administered the combined treatment having significantly decreased expression levels compared to saline-treated and minocycline-treated mice, and rapamycin-treated mice having reduced expression compared to minocycline-treated mice (H). Data are expressed as mean ± standard error of the mean (SEM). Differences in lettering indicate significance between groups at the level of p < 0.05.