Figure 3.

Effect of the IRAK4 inhibitor PF 06426779 on serum levels of immunoglobulins and autoantibodies in ABIN1[D485N] knock-in mice. (A) IgA; (B) IgM; (C) IgG2b; (D) IgG2a; (E) IgG1; (F) IgE; (G) ANA; (H) anti-double stranded DNA (anti-dsDNA). The measurements were made in wild-type and ABIN1[D485N] knock-in mice at the ages indicated. Where indicated (+) the R&M3 diet included PF 06426779 (4 g/kg) from the age of 13 weeks until the mice were culled at the age of 23 weeks. Different mouse cohorts were used for the studies at 13 and 23 weeks. Each symbol shows the result from a single individual mouse. Statistical significance was calculated using the Kruskal-Wallis and the Mann-Whitney U tests; * denotes p<0.05, ** denotes p<0.01 and *** denotes p<0.001. The methodology used is detailed in Nanda et al.⁶