Figure 1.

A schematic diagram of the treatment schedule and study design. In the intervention group, patients will take aspirin (300 mg loading and 100 mg/day), clopidogrel (300 mg loading and 75 mg/day) and high-intensity statins (atorvastatin 40–80 mg/day or rosuvastatin 20 mg/day) within 24 hours of stroke onset, followed by aspirin or clopidogrel alone from day 22. High-intensity statins includes atorvastatin 40–80 mg/day or rosuvastatin 20 mg/day. In the historical control group, patients will be selected from previous prospective studies if they fulfil the following inclusion criteria: took aspirin or clopidogrel alone and did not receive high-intensity statin treatment.