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. 2021 Nov 29;19:485. doi: 10.1186/s12967-021-03154-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Comparison of the microbiome composition in four different tissue types. a Patients were divided into four subgroups by adding prognostic information that was retrospectively determined (RC: recurrence; nRC: nonrecurrence), accompanied by normal tissue- and tumor-derived microbiomes, i.e., ‘N_crc_RC’, ‘N_crc_nRC’, ‘T_crc_RC’, and ‘T_crc_nRC’, as described in the main text. Differences in microbial composition are displayed at the phylum (left) and species levels (right). b Box plot analysis of the relative abundance of selected OTUs at the phylum level (top) and the species level (bottom) between ‘N_crc_RC’ and ‘N_crc_nRC’. c Box plot analysis of the relative abundance of selected OTUs at the phylum level (top) and the species level (bottom) between ‘T_crc_RC’ and ‘T_crc_nRC’. a, b The samples used were derived from a total of 33 ‘crc_nRC’ and 18 ‘crc_RC’ samples for both normal and tumor samples (Additional file 1: Table S1)