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. 2021 Nov 29;18:278. doi: 10.1186/s12974-021-02331-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Graphical summary of the proposed role of TonEBP in diabetes-induced neuroinflammation and memory deficits. During chronic diabetic conditions, systemic inflammation causes infiltration of neutrophils through blood–brain barrier leakage. This LCN2 production during chronic diabetes promotes TonEBP-mediated neuroinflammation, ultimately leading to memory deficits. In particular, TonEBP transcriptionally regulates LCN2 protein levels under diabetic conditions