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ADC linker technology and the release mechanism.
| ADC Linker Technology | Release Mechanism |
|---|---|
| Disulfide | Designed to be cleaved through disulfide exchange with an intracellular thiol, such as glutathione. |
| Hydrazone | Designed for serum stability and degradation in acidic compartments within the cytoplasm. |
| Peptide | Designed to be enzymatically hydrolyzed by lysosomal proteases such as cathepsin B. |
| Theoeither | Nonreducible and designed for intracellular proteolytic degradation. |
