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BLN1 mAb-mediated post-exposure protection against SARS-CoV-2 infection of K18-hACE2 mice. (A) Antibodies binding to immobilized SARS-CoV-2 spike protein. (B) in-vitro neutralization of SARS-CoV-2, by PRNT. (C,D) Animals were intranasally infected with SARS-CoV-2 and two days later treated with 100 µg/mouse of BLN1 (n = 6), BLN1-AG (n = 6) or with PBS as control (n = 6). (C) Kaplan–Meyer surviving curves. (D) Bodyweight profiles (data represents mean ± SEM).
