Fig. 8 |. Non-β cells do not generate new β cells in adults under pathological conditions.

Cartoon image showing labeling of β cells and non-β cells simultaneously. Non-β cells, including α-cells, δ-cells, PP-cells, acinar cell, duct cells and et al., do not generate new β cells under homeostatic and pathological conditions (top). Non-β cells do generate new Ins⁺ cells in adults after extreme loss of existing β cells (bottom).