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. Author manuscript; available in PMC: 2021 Nov 29.
Published in final edited form as: Biol Psychiatry. 2019 Aug 21;87(5):462–472. doi: 10.1016/j.biopsych.2019.08.005

Table 2.

Results of our gPPI analyses.

Group contrast Subject contrast ROI punc pFWE
(cluster)		 pFWE
(analysis)		 Size
(voxels)		 Test Z Peak
(x y z)		 Region
MDD vs HC
NoGo>Go - - - - - - - - -
ΔNoGo>Go - - - - - - - - -
NoGogPPl>GogPPl All - - - - - - - - -
ΔNoGogPPl>GogPPl Rt SMG 0.002 0.012 0.216 589 4.74 4.60 44 −58 34 Rt angular
Others - - - - - - - - -
Treatment × Response
NoGo>Go - - - - - - - - -
ΔNoGo>Go - - - - - - - - -
NoGogPPl>GogPPl Rt MTG 0.007 0.048 0.864 331 13.40 4.39 −18 −70 42 L superior parietal
Rt MFG1 6.28*10−5 4.89*10−4 8.80*10−3 778 14.89 4.63 68 −30 28 Rt supramarginal
Rt SMG 3.47*10−8 2.68*10−7 4.83*10−6 1854 19.11 5.27 52 −52 −4 Rt middle temporal
0.003 0.024 0.432 360 15.50 4.74 −40 −68 0 L inferior occipital
Cerebellum 0.001 0.008 0.144 413 14.84 4.63 −16 −62 54 L superior parietal
Others - - - - - - - - -
ΔNoGogPPl>GogPPl All - - - - - - - - -
EscR>EscNR
NoGo>Go - - - - - - - - -
ΔNoGo>Go - - - - - - - - -
NoGogPPl>GogPPl All - - - - - - - - -
ΔNoGogPPl>GogPPl Rt SMG 0.003 0.015 0.270 495 4.13 3.98 16 −38 −4 Rt lingual
Others - - - - - - - - -
SerR>SerNR
NoGo>Go - - - - - - - - -
ΔNoGo>Go - - - - - - - - -
NoGogPPl>GogPPl Rt MFG1 0.002 0.013 0.234 549 4.70 4.48 −24 42 42 L superior frontal
0.001 0.005 0.090 692 4.34 4.17 −8 −42 42 L precuneus
0.002 0.011 0.198 571 4.29 4.13 64 −32 32 Rt supramarginal
Rt SMG 3.97*10−5 2.22*10−4 0.004 1197 5.33 5.03 52 −50 −6 Rt middle temporal
0.001 0.005 0.090 692 4.65 4.45 −40 −68 0 L inferior occipital
Cerebellum 1.59*10−4 0.001 0.018 829 5.02 4.76 −42 2 −6 L anterior insula
0.005 0.033 0.594 385 5.01 4.75 −14 −76 36 L precuneus
Others - - - - - - - - -
ΔNoGogPPl>GogPPl L PCG 3.88*10−4 0.002 0.036 745 4.85 4.62 −62 −10 −10 L middle temporal
Rt MFG2 0.001 0.007 0.126 642 5.02 4.77 −52 −42 −2 L middle temporal
Others - - - - - - - - -
VenR>VenNR
NoGo>Go - - - - - - - - -
ΔNoGo>Go - - - - - - - - -
NoGogPPl>GogPPl All - - - - - - - - -
ΔNoGogPPl>GogPPl L OFC 6.01*10−6 3.21*10−5 0.001 1548 5.16 4.89 6 −2 −6 Rt ventral diencephalon
0.006 0.029 0.522 440 4.34 4.17 10 26 2 Rt caudate
Others - - - - - - - - -

Results from our analyses comparing activation or functional connectivity in the NoGo versus the Go condition and the longitudinal changes (Δ) in this contrast. For brevity, we show only results surviving a cluster-level correction within their respective general linear models of pFWE<0.05. To account for testing of multiple models, after this step, another family-wise error correction was applied on the 18 surviving clusters across all models. Results surviving the analysis-level correction are highlighted in bold and are our main findings. We also show which models did not return any findings surviving the within-model cluster-level correction step (dashes). Coordinates of peak values are in MNI space. ROI abbreviations match the ones reported in Table 1. Test values are F for the Treatment × Response interaction and T for all other contrasts.

Abbreviations: gPPI=generalized psychophysiological interaction, L=left, MFG=middle frontal gyrus, MTG=middle temporal gyrus, NR=non-responders, OFC= orbitofrontal cortex, PCG=postcentral gyrus, pFWE=family-wise error corrected p, pUNC=uncorrected p, R=responders, Rt=right, ROI=region of interest, Ser=sertraline, SMG=supramarginal gyrus, Ven=venlafaxine.